Metabolic phenotypes and pulmonary function in aging: the mediating roles of cognitive function and depression in CHARLS.

ABSTRACT:

Background

Metabolic phenotypes, defined by weight status and metabolic health, influence various physiological outcomes, yet their impact on pulmonary function in aging populations remains unclear. This study examines the longitudinal association between metabolic phenotypes and peak expiratory flow (PEF), considering the mediating roles of cognitive function and depression.

Methods

We analyzed longitudinal data (2011-2015) from 4,393 participants (mean age 58.9 years; 56.7% female) in the China Health and Retirement Longitudinal Study (CHARLS). Participants were categorized into four metabolic phenotypes: metabolically healthy normal weight (MHNW), metabolically healthy overweight/obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overwe

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12577114 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature