Prognostic model for early gastric cardia cancer after endoscopic submucosal dissection.

ABSTRACT:

Objective

To develop and validate a prognostic model incorporating microRNA-1246 (miR-1246), high-mobility group box 1 (HMGB-1), α1-antitrypsin (A1AT), and inflammatory markers for predicting outcomes in early gastric cardia cancer after endoscopic submucosal dissection (ESD).

Methods

We retrospectively enrolled 280 patients with early gastric cardia cancer who underwent ESD between January 2021 and December 2023. Patients were divided into a training set (n = 196) and a validation set (n = 84) at a ratio of 7:3. Influencing factors were screened using univariate, Least Absolute Shrinkage and Selection Operator (LASSO), and multivariate logistic regression analyses in the training set. A nomogram was constructed, and the predictive performance was assessed using receiver ope

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12577123 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature