Volumetric analysis of hippocampal subregions in migraine without aura: an exploratory study on mechanisms underlying migraine chronification.

ABSTRACT:

Background

Previous neuroimaging studies on migraine have reported inconsistent hippocampal volumetric changes, potentially due to insufficient consideration of subregion heterogeneity. Exploring the alterations in hippocampal subregions may help reveal the mechanisms underlying migraine chronification. This study aims to investigate the role of volume changes in these subregions in migraine chronification.

Methods

Structural T1-weighted MRI scans were performed on 42 patients with episodic migraine (EM), 22 patients with chronic migraine (CM), and 65 healthy controls (HCs). Hippocampal subregion volumes were quantified using FreeSurfer-based segmentation, and group comparisons were performed with relevant covariates included and false discovery rate (FDR) correction applied

SUBMITTER: Feng Q 

PROVIDER: S-EPMC12577149 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature