Gellan gum/gelatin Schiff-base hydrogel for ocular drug delivery of timolol maleate.

ABSTRACT: In ocular drug delivery, increasing the retention time of the drug by using in situ forming hydrogels can be effective. In the current study, hydrogels with suitable gelling properties were obtained using oxidized gellan gum as a green crosslinker and gelatin via Schiff-base linkages. In the first step, oxidation of gellan gum was done to obtain aldehyde groups, and in situ gelling hydrogels were formed based on a simplistic Schiff-base reaction between oxidized gellan gum and amine groups of gelatin in the presence of β-glycerophosphate disodium salt as a pH adjustment agent and gelation accelerator. The calculated aldehyde content was about 64.5% by the titration method. By optimizing the concentration of gelatin, oxidized gellan gum, and β-glycerophosphate disodium salt, hydrogels with

SUBMITTER: Shajari G 

PROVIDER: S-EPMC12577232 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature