Delineating markers of disease-disease interaction: a systematic methodology and its application to multiple diabetes-helminth cohorts.

ABSTRACT:

Background

Understanding how the molecules in our bodyrespond to the co-occurrence of two diseases in an individual (comorbidity) could lead tomechanistic insights into novel treatments for comorbid conditions. Studies have shown forinstance, that responses of our immune system to comorbid conditions could be more complexthan the union of immune responses to each disease occurring separately, but a data-drivenquantification of this complexity is lacking.

Results

In this study, we present a systematicmethodology to quantify the interaction effect of two diseases on marker variables of interest(using a chronic inflammatory disease diabetes and parasitic infection helminth as illustrativedisease pairs to identify cytokines or other immune markers that respond distinctively unde

SUBMITTER: Subramanian N 

PROVIDER: S-EPMC12577264 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature