Nano-size tantalum particles suppress the osteogenic activity of osteoblasts and stimulate osteoclasts.

ABSTRACT:

Background

Tantalum (Ta) and its derivatives are inert, possess mechanical qualities such as corrosion resistance, and are biocompatible. They also offer structural support during surgical correction, such as bone grafts during surgery, in instances of dental or skeletal disabilities. However, various sizes of Ta particles could be expelled from the implant's surface due to mechanical stress and load-induced wear caused by micromotion between loose implant surfaces during usage. Therefore, the study examined the effects of nano (25 nm) and micro-sized Ta particles (10 μm and 40-50 μm) on osteoblasts and osteoclasts.

Results

Osteoblasts efficiently phagocytosed 25 nm sized Ta particles compared to micro-sized particles and triggered significant biological effects. Only 25 nm

SUBMITTER: Sharma AR 

PROVIDER: S-EPMC12577323 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature