Mid-term outcomes of paclitaxel-coated balloon for de novo non-small coronary lesions: a pooled analysis.

ABSTRACT:

Background

The efficacy of drug-coated balloons (DCB) for the treatment of de novo, non-small coronary lesions remains uncertain. This study aimed to evaluate the real-world performance of DCB-only angioplasty in this setting.

Methods

Patients with de novo, non-small coronary lesions (≥ 2.5 mm) treated exclusively with either drug-eluting stents (DES) or DCB were included from the DCB registry and two DES registries. The primary endpoint was the device-oriented composite endpoint (DoCE), including cardiovascular death, non-fatal target vessel myocardial infarction (TV-MI), and target lesion revascularization (TLR). Differences between cohorts were compared and adjusted by inverse probability of treatment weighting (IPTW).

Results

The study included 4621 patients, with

SUBMITTER: He X 

PROVIDER: S-EPMC12577343 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature