Investigating the role of homocysteine and B vitamins in gestational diabetes mellitus: Mendelian randomization study.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is a significant pregnancy complication, and its relationship with serum levels of B vitamins and homocysteine (Hcy) remains unclear. This study aims to investigate the causal associations between genetically predicted serum levels of B vitamins (vitamin B6, B12, and folate) and Hcy with GDM risk.

Methods

Independent single nucleotide polymorphisms (SNPs) associated with Hcy (n = 14), Hcy (independent of BMI) (n = 11), vitamin B6 (n = 16), vitamin B12 (n = 8), folate (n = 14), and folate (independent of BMI) (n = 13) were selected as instrumental variables (IVs) based on genome-wide significance. Summary-level data for GDM were sourced from the FinnGen consortium.

Results

The MR analysis demonstrated a significant associa

SUBMITTER: Zhan X 

PROVIDER: S-EPMC12577385 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature