Association of non-alcoholic fatty liver polygenic risk scores with the incident and progressive non-alcoholic fatty liver disease in Chinese population.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is an escalating health concern, with genetic factors playing a substantial role. This study aimed to establish and validate a polygenic risk score for East Asian populations (PRS-EA).

Methods

A meta-analysis of genome-wide association studies on NAFLD in East Asian populations was conducted to develop a PRS-EA model. This model was subsequently validated in the Kailuan cohort by exploring its association with NAFLD development and progression.

Results

A PRS-EA model involving four SNPs (rs2896019, rs3810622, rs58542926, and rs1260326) was constructed. Individuals with PRS-EA scores exceeding 2.33 were associated with a 53% (95% confidence interval, 3%-126%) increased risk of NAFLD development and 50% (95% confidence

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12577390 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature