Clinicopathological significance of AKT and phosphorylated AKT expression in hepatocellular carcinoma: A Meta-Analysis.

ABSTRACT:

Background

The implications of AKT and phospho-AKT (p-AKT) expression patterns in various malignancies remain a subject of considerable scientific interest. Current evidence regarding their association with hepatocellular carcinoma (HCC) progression by immunohistochemical (IHC) analyses demonstrates significant inconsistencies.

Objective

This study aimed to evaluate the clinical significance of AKT and p-AKT expression in HCC patients, with specific emphasis on their correlations with clinicopathological parameters, to provide insights to inform clinical decision-making.

Method

We conducted a systematic literature search across six major electronic databases through February 25, 2024, using search terms related to AKT, p-AKT, IHC, and hepatocellular carcinoma. Eligibl

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12577396 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature