Comparative efficacy and safety of cabazitaxel versus other taxanes: a systematic review and meta-analysis.

ABSTRACT:

Background and objectives

This systematic review addresses uncertainty around cabazitaxel's effectiveness, safety, and optimal dosing compared to other taxanes, aiming to guide personalized treatment and improve patient outcomes.

Methods

A meta-analysis of randomized controlled trials (RCTs) assessed the efficacy and safety of cabazitaxel, including tumor response, survival rates, and toxicity profiles. Trials were identified from several databases, and the bias was evaluated by using the Cochrane RoB 2 tool. Review Manager (RevMan 5.4) was used for heterogeneity testing, sensitivity analyses, pooling hazard ratio (HR) and risk ratios (RR) with 95% confidence intervals (CI), and publication bias assessment.

Results

This meta-analysis included 10 trials with 3,377 pati

SUBMITTER: Abdu SA 

PROVIDER: S-EPMC12577412 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature