Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity.

ABSTRACT:

Background

Malaria, caused by Plasmodium parasites, remains a leading global health concern, impacting millions of people globally. Splenic macrophages are specialized immune cells that reside in the spleen and play a pivotal role in the pathogenesis and immune response during malaria. These cells are fundamental to the body's defense against Plasmodium due to their multifaceted roles in parasite clearance, antigen presentation, and immune regulation. They participate in the early immune response by phagocytosing infected red blood cells, producing cytokines, and interacting with other immune cells to modulate both pro-inflammatory and anti-inflammatory responses.

Aim

This review highlights the evolving understanding of splenic macrophages in malaria pathogenesis and immunit

SUBMITTER: Gupta A 

PROVIDER: S-EPMC12577441 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature