FAK-dependent activation of src family kinase member BLK contributed to endometrial fibrosis via endoplasmic reticulum stress.

ABSTRACT:

Background

While Src family kinases (SFKs) are established mediators of some fibrotic diseases, their specific function in endometrial fibrosis is not well defined. Here, we investigated the function and underlying mechanism of B lymphoid tyrosine kinase (BLK), an SFK member, in driving endometrial fibrosis.

Methods

BLK expression was analyzed in the human endometrium and mice uterus, as well as in human endometrial stromal cells (hEndoSCs). Its functional role was assessed using siBLK in TGF-β1-induced hEndoSCs and in the intrauterine adhesion (IUA) mice model with Blk knockdown (IUA^Blk[LKD]).

Results

BLK was overexpressed and activated in the endometrium of IUA patients, the uterus of IUA mice, and TGF-β1-induced hEndoSCs, and was accompanied by high expr

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12577442 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature