Diagnostic and prognostic implications of growth differentiation factor 15 in heart failure with preserved ejection fraction: a systematic review and meta-analysis.

ABSTRACT:

Background

Growth differentiation factor-15 (GDF-15), an emerging biomarker associated with chronic inflammation and oxidative stress, shows potential diagnostic and prognostic significance for heart failure with preserved ejection fraction (HFpEF). This study aimed to assess the diagnostic and prognostic value of GDF-15 in HFpEF.

Methods

Three databases (PubMed, Scopus, and ScienceDirect) were used to search for relevant literature published before August 6, 2024. Quality assessment was conducted using the Newcastle-Ottawa scale and its adaptation for cross-sectional studies. Statistical analysis was performed using RStudio version 4.4.1. All meta-analyses employed a random-effects model. Sensitivity analysis was conducted using the leave-one-out technique to evaluate the i

SUBMITTER: Dakota I 

PROVIDER: S-EPMC12577569 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature