Designing halogen-free metal-phenolic imidazolium poly(ionic liquids) with multi-functional antibacterial, anti-inflammatory and cell proliferation properties for infected wounds.

ABSTRACT: Infected wounds are challenging to heal because they are complicated by bacterial infections, persistent inflammation, and impaired cell proliferation. Recently, imidazolium poly(ionic liquids) (PILs), as highly effective antibacterial agents, have been developed for infected wound healing. However, traditional imidazolium-based PILs containing halogen groups have shown potential cytotoxicity. In this study, we designed halogen-free metal-phenolic imidazolium PILs (HMPIPs) with antibacterial, anti-inflammatory and cell proliferation properties. Firstly, poly(vinyl-butylimidazolium dihydroxyphenylpropionic acid) (PVD) was synthesized via radical polymerization, anion exchange, and catechol deprotection. Subsequently, the HMPIPs were individually coordinated with metals ions (Zn²

SUBMITTER: Wang D 

PROVIDER: S-EPMC12577589 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature