Effects of Preoxygenation With Intratracheal Suctioning During Extubation: An Alternating Cluster-Controlled Trial (INtratracheal suctioning and oxygenation AT Extubation [INNOVATE]).

ABSTRACT:

Objective

Extubation is a critical event for patients in the ICU. Preoxygenation and intratracheal suctioning during extubation may contribute to atelectasis. However, evidence concerning extubation procedures and their impact on patient outcomes is limited. This study aimed to compare two extubation strategies: one using preoxygenation with 100% Fio2 combined with intratracheal suctioning, and the other using a low Fio2 (35%) without suctioning.

Design

A single-center, alternating cluster-controlled trial.

Setting

Tertiary level interdisciplinary adult ICU.

Patients

A total of 3,675 patients were randomized into two groups: 1) Fio2 100% with suctioning (n = 1,877, 51.1%) and 2) Fio2 35% without suctioning (n = 1,798, 48.9%).

Interventions

Comparison of

SUBMITTER: Prazak J 

PROVIDER: S-EPMC12577658 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature