Heart Rate Profiles During Exercise and Incident Parkinson's Disease.

ABSTRACT:

Objective

To determine whether established heart rate parameters of exercise, related to cardiac autonomic function, are associated with incident Parkinson's disease, independent of both clinical and autonomic prodromal features.

Methods

A study of UK Biobank participants who performed a standardized bicycle exercise test (2009-2013), followed until November 2022, and analyzed in January 2024, was carried out. Heart rate increase from rest to exercise, and heart rate decrease from peak exercise to recovery were associated with incident Parkinson's disease. Multivariable adjustment was performed both for clinical characteristics and for prodromal non-cardiac autonomic features.

Results

A total of 69,288 eligible participants (men 48%, mean age 56.8 years [SD 8.2 years]

SUBMITTER: van Duijvenboden S 

PROVIDER: S-EPMC12577668 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature