Ni-catalyzed enantioselective synthesis of β-aminoboronates via spin-center shift and proton transfer.

ABSTRACT: The spin-center shift (SCS) process, involving 1,2-radical migrations, plays a pivotal role in both biological transformations and organic synthesis. While the potential of combining SCS with transition metal-catalyzed enantioselective reductive coupling of electrophiles to construct Csp³-Csp³ bonds at remote positions is highly attractive, this strategy has remained unexplored to date. Here, we report an enantioselective Ni-catalyzed reductive cross-coupling for the synthesis of β-aminoboronates. Our catalytic system operates under mild conditions, achieving excellent enantioselectivity while maintaining broad functional group compatibility. Mechanistic studies, including detailed density functional theory (DFT) calculations, demonstrate the synergistic involvement o

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12577675 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature