Cascade-targeting pH/ROS microneedles promote scarless diabetic wound healing by macrophage metaboimmune reprogramming.

ABSTRACT: Precise macrophage modulation is essential for diabetic wound treatment, yet mitochondrial dysfunction often sustains proinflammatory states. We developed cascade-targeting nanoparticles [epigallocatechin-3-gallate and metformin nanoparticles modified with mannose (EM/Man NPs)] to regulate macrophage mitochondria, integrated into a detachable core-shell microneedle patch (EM/Man MNs) made of quaternary ammonium chitosan and reactive oxygen species (ROS)-degradable polymer. The patch offered high penetration and antibacterial activity, while its ROS-sensitive core released EM/Man NPs to scavenge ROS, restore adenosine 5'-triphosphate production, and reestablish redox balance. The NPs further activated the adenosine 5'-monophosphate-activated protein kinase/Sirtuin 1/peroxisome proliferator-

SUBMITTER: Yang G 

PROVIDER: S-EPMC12577711 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature