Evaluating the Effect of Drug Loading on the Acoustic Response of Nanobubbles in Stable and Inertial Cavitation Regimes.

ABSTRACT: Nanobubbles (NBs) have been investigated as ultrasound contrast agents and drug delivery carriers in medical applications. Previous studies have reported the efficacy of NBs in imaging and therapy. However, ultrasound (US) exposure parameters for stable and inertial cavitation of NBs need to be investigated. This study examines passive cavitation detection of ultrasound signatures from two types of NBs across three pressure ranges using passive cavitation detection (PCD), aiming to investigate their cavitation behaviour with and without the inclusion of the chemotherapeutic drug, Doxorubicin (HDox). We compared the power spectral density (PSD) of non-drug loaded Propylene-Glycol Glycerol (PGG) NBs and HDox NBs under 300 kPa, 600 kPa, and 900 kPa pressures at 1 MHz fundamental frequency and

SUBMITTER: Khan MS 

PROVIDER: S-EPMC12577732 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature