The Impact of an Ex Vivo Pediatric Extracorporeal Membrane Oxygenation Circuit on Sequestration of Antimicrobials.

ABSTRACT:

Objectives

To determine if common antimicrobials (n = 11) are sequestered or degraded during a pediatric extracorporeal membrane oxygenation (ECMO) simulation.

Design

An ex vivo model of a closed ECMO circuit was established to simulate the treatment of a 3 kg infant. A control was used to quantify spontaneous antimicrobial degradation.

Setting

University research laboratory.

Participants

None.

Main outcomes and measures

The ECMO circuit was primed and maintained at physiologic pH and temperature for 7 hours. After baseline sampling, the antimicrobials were administered as a single bolus into the circuit. Eight plasma samples were taken from the controls and ECMO circuits over 7 hours. Antimicrobial concentrations were measured using validated high-perfo

SUBMITTER: Cree ML 

PROVIDER: S-EPMC12577806 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature