Understanding Cerebral Blood Flow Dynamics for Alzheimer's Disease Prevention Through Acute Exercise (flADex): Protocol for a Randomized Crossover Trial.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a leading cause of disability worldwide. Alterations in cerebral blood flow (CBF) and AD blood biomarkers are fundamental at early stages of AD. Exercise shows promise in delaying physiological changes, but its mechanisms for enhancing brain health remain unclear. flADex aims to examine the acute effects of different exercise types on CBF and blood biomarkers in older adults. This protocol describes the methodology and rationale of flADex.

Methods

flADex is a counterbalanced crossover trial in 20 older adults, aged 68-83 years old, with negative brain amyloid status (< 12 centiloid) who are APOEε4 noncarriers. Participants will complete a 30-min session of each condition in a randomized order: (i) moderate-intensity aerobic exercise (

SUBMITTER: Martin-Fuentes I 

PROVIDER: S-EPMC12577972 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature