Comparison of dexmedetomidine and cold thermotherapy for the relief of pain on propofol injection: A randomized controlled trial.

ABSTRACT:

Background and aims

Pain on propofol injection (POPI) leads to intense patient discomfort during the induction of anesthesia. This study aimed to compare the efficacy of intravenous dexmedetomidine and topical cold thermotherapy in the relief of POPI.

Material and methods

This randomized controlled trial was conducted on 274 adults undergoing elective surgery under general anesthesia. Patients received dexmedetomidine (0.25 µg/kg) following the application of a tourniquet proximal to the intravenous cannulation site for 30 s (Group D, n = 137), or an ice pack gel (260 mm × 125 mm) was applied proximal to the site of the cannula for 1 min (Group T, n = 137). The primary objective was to assess and compare the incidence and severity of POPI using the McCrirrick and Hunter Scal

SUBMITTER: Biswal M 

PROVIDER: S-EPMC12578017 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature