Conserved mode of nuclear lamina distortion by primate cytomegaloviruses: importance of the pSer22 motif, viral kinase and <i>cis</i>/<i>trans</i> isomerase Pin1 activity.

ABSTRACT: Human cytomegalovirus (HCMV) is a ubiquitous human pathogen of high clinical relevance. In terms of pathogenic determination, the regulatory factors of HCMV-host interaction play a crucial role, and recently we reported on virus-supportive functions of the cellular peptidyl-prolyl cis/trans isomerase Pin1. Notably, Pin1 is able to recognize phosphorylated serine/threonine-proline motifs and regulate the structural conformation, stability and function of its substrate proteins. During HCMV replication, Pin1 facilitates viral nuclear egress by inducing site-specific rearrangements of the nuclear lamina through the cis/trans conversion of lamin type A/C. To this end, we developed readout systems to decipher details of HCMV-Pin1 regulatory interaction. Notably, toge

SUBMITTER: Dhotre K 

PROVIDER: S-EPMC12578131 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature