Molecular genetic portrait of virulence and ciprofloxacin resistance genes in clinical Pseudomonas aeruginosa Isolates from Khartoum, Sudan.

ABSTRACT:

Background

Pseudomonas aeruginosa remains a major cause of hospital- and community-acquired infections, with increasing ciprofloxacin resistance driven by mutations in quinolone resistance-determining regions (QRDRs) and plasmid-mediated mechanisms. This study aimed to determine the prevalence of key virulence genes (oprI, toxA, lasB, nan1) and ciprofloxacin resistance determinants (gyrA, parC, qnrA, qnrB, qnrS) in clinical isolates from Khartoum State, Sudan, and to explore associations with demographic and clinical variables.

Methods

This cross-sectional study, which was conducted from January to April 2023, included eighty-six clinical isolates of P.aeruginosa that were collected from various hospitals in Khartoum State. The isolates were reidentified via standard microbi

SUBMITTER: Abdallah ASI 

PROVIDER: S-EPMC12578343 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature