Inference of weak-form partial differential equations describing migration and proliferation mechanisms in wound healing experiments on cancer cells.

ABSTRACT: Cancer metastasis, which requires migration of cancer cells away from the primary tumor, is responsible for approximately 65% percent of cancer-related deaths. Therefore, targeting signaling pathways that drive cancer cell migration or proliferation is a common therapeutic approach. Cell migration is commonly studied using experimental approaches which track cells or cell monolayers as they evolve over time. Computational modeling can then be used to fit partial differential equation (PDE) models to the data, providing mechanistic insights underlying the observed cell motion, including the contribution of various cellular behaviors such as random motion, directed motion, and cell division. A popular experimental technique, the scratch assay, measures the migration and proliferation-driven

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC12578354 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature