Performance of DOAC and HAS-BLED scores in predicting major bleeding in Asian patients with non-valvular atrial fibrillation receiving direct oral anticoagulants.

ABSTRACT:

Aims

The direct oral anticoagulant (DOAC) score was recently developed to predict bleeding risk in patients with atrial fibrillation (AF) receiving oral anticoagulants. However, limited data show inconsistent results comparing its performance to the conventional HAS-BLED score in Asian populations with non-valvular AF receiving DOACs.

Methods and results

We enrolled 21 142 patients with non-valvular AF receiving DOACs from a multicentre database in Taiwan (June 2012-December 2021). The primary endpoint was major bleeding events. Major bleeding events were defined according to the ISTH criteria. Areas under receiver operating characteristic curves (AUCs) were calculated for each score, with differences assessed using DeLong test. A total of 21 142 AF patients (mean age 75.9 ±

SUBMITTER: Chan YH 

PROVIDER: S-EPMC12578370 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature