Effectiveness of Mycophenolate Mofetil Among Patients With Progressive IgA Nephropathy: A Randomized Clinical Trial.

ABSTRACT:

Importance

The role of mycophenolate mofetil (MMF) in management of immunoglobulin A nephropathy (IgAN) remains highly controversial.

Objective

To evaluate the efficacy and safety of MMF in patients with IgAN at high risk of kidney function loss.

Design, setting, and participants

This randomized clinical trial with open-label, blinded end-point design was conducted among adults with IgAN, proteinuria greater than 1.0 g/d, and estimated glomerular filtration rate (eGFR) greater than 30 and less than 60 mL/min/1.73m2 or with persistent hypertension from September 2013 to December 2015. During a 3-month run-in period, 238 patients received optimized supportive care (SC), including losartan. Patients with a urinary protein excretion rate of 0.75 g/d or greater despite of

SUBMITTER: Hou FF 

PROVIDER: S-EPMC12578496 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature