CircANKRD52 Augments the Growth and Invasion of Melanoma Cells by Sponging miR-141-3p and Upregulating PRKACB.

ABSTRACT: Accumulating data have shown that circRNAs act pivotal roles in cancer progression. However, the role and molecular mechanism of circRNAs in melanoma remain undocumented. GEO dataset was used to identify the differentially expressed circRNAs between melanoma and normal tissues, and the expression and prognosis of circANKRD52 (hsa_circ_0026926) in melanoma were assessed by qRT-PCR analysis. EdU, Transwell, Flow cytometry analysis, human umbilical vein endothelial cells (HUVECs) coculture assay as well as in vivo tumourigenesis models were utilised to assess cell growth and invasion. The specific binding between circANKRD52 and miR-141-3p was confirmed by bioinformatic analysis, RIP, RNA pull-down, and luciferase reporter assays. The effect of circANKRD52 or miR-141-3p on PRKACB expression w

SUBMITTER: Chu S 

PROVIDER: S-EPMC12578596 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature