Association between diabetic peripheral neuropathy and lower limb muscle strength in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

ABSTRACT:

Purpose

Lower limb muscle strength is often reduced in patients with type 2 diabetes and is associated with a lower quality of life and poorer walking ability. Diabetic peripheral neuropathy (DPN) may contribute to muscle weakness, though evidence is inconsistent. No meta-analysis has specifically examined the effect of DPN on lower limb muscle strength. This study aimed to review the literature and assess whether lower limb muscle strength is reduced in individuals with DPN compared to those without DPN.

Methods

MEDLINE, Embase, and CENTRAL were searched for cohort and case-control studies on the association between DPN and lower limb muscle strength in individuals with type 2 diabetes. We pooled mean differences and standard deviations using random effects models. We evalu

SUBMITTER: Nakashima Y 

PROVIDER: S-EPMC12578673 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature