Bidirectional modulation of reward-guided decision making by dopamine.

ABSTRACT:

Rationale

The neuromodulator dopamine is known to play a key role in reward-guided decision making, where choice options are often characterized by multiple attributes. Different decision strategies can be used to merge these choice attributes with personal preferences (e.g., risk preferences) and integrate them into a single subjective value. While the influence of dopamine on risk preferences has been investigated, it is unknown whether dopamine is also involved in arbitrating between decision strategies.

Objective

In the present study, we investigate the effects of pharmacological dopamine manipulations on arbitrating between different decision strategies in a healthy sample.

Methods

31 healthy male participants performed a reward-guided decision-making task under

SUBMITTER: Dias Maile AA 

PROVIDER: S-EPMC12578710 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature