Systemic davunetide provides sex-specific neuroprotection during Coronary Artery Bypass Grafting (CABG).

ABSTRACT: Coronary artery bypass grafting (CABG) is a surgical procedure commonly employed to treat severe coronary artery disease by improving blood flow to the heart. Despite its effectiveness, CABG is an open-heart surgery associated with potential complications, including cognitive decline, a currently unmet need. Discovered in our laboratory, activity-dependent neuroprotective protein (ADNP) is essential for brain formation as well as heart development and embryogenesis and the ADNP-derived investigational drug, davunetide, ameliorates partly ADNP-linked deficiencies. Specifically, davunetide was found to be efficacious in a rat pre-clinical model of ischemic stroke, a potential unwanted side effect of CABG, which may lead to a neurodegenerative process, culminating in cognitive dysfunction. He

SUBMITTER: Gozes I 

PROVIDER: S-EPMC12578781 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature