Social support facilitates threat extinction retention in humans: an fMRI study.

ABSTRACT: Extinction is a recognized process for extinguishing threat memories; however, the process of extinction can be emotionally challenging, and the effect is usually short-lived. Animal studies have shown that peer presentation can inhibit freezing behavior and prevent return of the threat memories, suggesting that social support may enhance threat extinction. However, the role of social support in maintaining human threat extinction remains unclear. The present study examined the effect of social support on threat memory extinction in humans, and its underlying neural substrates. Succeeding threat conditioning on Day 1, participants were randomly assigned to the social support and no-support groups using random numbers and experienced either a social support intervention or no intervention b

SUBMITTER: Gong Y 

PROVIDER: S-EPMC12578800 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature