Independent validation of lung adenocarcinoma prognostic risk scores incorporating cholesterol and estrogen metabolism related transcriptional biomarkers.

ABSTRACT: We investigated the prognostic significance of cholesterol metabolism-related genes (CMRGs) and estrogen metabolism-related genes (EMRGs) in lung adenocarcinoma (LUAD). Transcriptomic and clinical data from the cancer genome atlas (TCGA) and gene expression omnibus (GEO) databases were analyzed. Iterative sure independence screening and least absolute shrinkage and selection operator (ISIS-LASSO) Cox regression identified prognostic CMRGs and EMRGs. Two risk scores-Cholescore and Estrogenscore-were constructed and validated. High Cholescore was associated with poor overall survival (OS), reduced immune infiltration, low immune checkpoint expression, and high tumor purity, suggesting an immunosuppressive tumor microenvironment. Estrogenscore also independently predicted LUAD prognosis. Medi

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC12578827 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature