Antimicrobial effects and mechanisms of hydrogen sulphide against nail pathogens.

ABSTRACT: Nail infections are common but challenging to treat. Oral treatments can be effective but may cause adverse effects and drug interactions, while topical treatments only work in about a third of patients due to poor penetration of antifungals into the nail plate. Small polar molecules, such as hydrogen sulphide (H₂S), penetrate readily into the nail plate, and previous studies have shown that H₂S has antimicrobial properties. Using the donor sodium hydrogen sulphide (NaHS), we found that H₂S has potent activity against causative agents of nail infections, including fungi and bacteria. The most active form appeared to be H₂S, not the anion HS^-, but this was most likely related to the faster cellular uptake of H₂S. We showed th

SUBMITTER: Ho FK 

PROVIDER: S-EPMC12578836 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature