Androgen receptor gene polymorphism and biological age markers in men.

ABSTRACT: Inter-individual differences in aging rates may stem from the trade-offs between reproductive effort and somatic maintenance, with higher reproductive effort potentially reducing healthspan and lifespan. In men, these trade-offs are thought to be regulated by androgens, where high androgen levels incur biological costs. However, the relationship between androgen levels, health, and aging is complex, and the role of androgen receptor (AR) sensitivity in aging remains unclear. Thus, this study aimed to investigate whether genetic polymorphisms in the AR gene, related to receptor affinity and androgen sensitivity, predict biological age in men. The analyses included 131 healthy men (mean age: 35.4, age range 30-45). Biological age was assessed using physiological markers, including klotho, in

SUBMITTER: Zelazniewicz A 

PROVIDER: S-EPMC12578872 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature