A design for an efficient functional panel that determines platelet exhaustion levels to differentiate responder and non-responder ITP patients.

ABSTRACT: Immune thrombocytopenia (ITP) is marked by decreased platelet counts and an increased bleeding risk, while functional platelet exhaustion may also underlie its clinical variability. This study investigates whether platelet functional competence can help differentiate "responder" (R) from "non-responder" (NR) ITP patients. Platelets obtained from 28 chronic ITP patients and 20 healthy controls, either in resting condition or in the presence of PMA, were subjected to flow cytometry, where the levels of platelet activation markers (P-selectin expression, PAC-1 binding) and reactive oxygen species (ROS) were assessed. In ITP, baseline levels of P-selectin and PAC-1 were higher compared to healthy controls, while their levels in response to PMA were significantly lower (p˂0.05). Baseline ROS al

SUBMITTER: Heidari N 

PROVIDER: S-EPMC12578879 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature