Therapeutic deep brain stimulation targeting BNST-NAc circuit driven large-scale brain networks in treatment-resistant depression.

ABSTRACT: Therapeutic deep brain stimulation (DBS) targeting the striatum shows promise for treatment-resistant depression (TRD), but its effects on large-scale brain network dynamics remain unclear. This study aimed to elucidate how DBS targeting the bed nucleus of the stria terminalis-nucleus accumbens (BNST-NAc) circuit modulates network dynamics, assessed via electroencephalography (EEG) microstates, and how these changes relate to local circuit activity. In a randomized, double-blind, crossover trial with 10 TRD patients, synchronous resting-state scalp EEG and NAc local field potential (LFP) data were collected during active and sham stimulation. Microstate analysis identified five consistent microstates (A-E). Compared to sham, therapeutic DBS increased the coverage and occurrence of microsta

SUBMITTER: Ye K 

PROVIDER: S-EPMC12578899 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature