<i>Aggregatibacter</i><i>aphrophilus</i> T6SS Effectors in Host-Bacterial Interactions.

ABSTRACT: Aggregatibacter aphrophilus is the only known oral bacterium with a functional type VI secretion system (T6SS) that acts against Aggregatibacter actinomycetemcomitans. Bacteria use the T6SS to deliver toxic effectors into bacterial or eukaryotic cells during interbacterial competition or host colonization. To date, the T6SS of A. aphrophilus has not been demonstrated to participate in antieukaryotic activity, nor have the cytotoxic effectors involved been identified. Here, we identified 2 T6SS effectors in A. aphrophilus, a glycosyl hydrolase (Glh) and a phospholipase D (Tle5), which, upon inactivation of their respective genes, together resulted in abolished T6SS activity against A. actinomycetemcomitans in multispecies biofilms. Next, we probed the role

SUBMITTER: Bao K 

PROVIDER: S-EPMC12578953 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature