Widespread alterations of white matter integrity in medication-free obsessive-compulsive disorder.

ABSTRACT: Previous studies have highlighted alterations of white matter (WM) integrity underlying mechanisms of obsessive-compulsive disorder (OCD). However, whole-brain WM abnormalities in OCD at the tract-level still remain largely unknown. In current study, we evaluated the integrity of 42 WM tracts in individuals with OCD using the novel tractography toolbox, TRActs Constrained by UnderLying Anatomy (TRACULA), and investigated the grey matter changes linked to the white matter alterations. Furthermore, we investigated the association of diffusion measures with clinical symptom severity. DTI and T1-weighted image data were collected from 54 medication-free OCD patients and 39 age- and sex-matched healthy controls (HCs). TRACULA was used to reconstruct 42 WM tracts and produce tract volume, fracti

SUBMITTER: Chai S 

PROVIDER: S-EPMC12578979 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature