Ultrasound-derived fat fraction for the noninvasive quantification of hepatic steatosis: a prospective multicenter study.

ABSTRACT:

Objectives

To prospectively evaluate the diagnostic accuracy of ultrasound-derived fat fraction (UDFF) in quantifying hepatic steatosis, to establish and validate a dual-threshold UDFF classification system, and to investigate its efficacy for risk stratification in body mass index (BMI)-defined subgroups.

Materials and methods

This prospective multicenter study involved 790 suspected metabolic dysfunction-associated steatotic liver disease (MASLD) participants from April 2023 to November 2024 (derivation: n = 553; validation: n = 237). Liver biopsy histopathology (n = 342), MRI proton density fat fraction (MRI-PDFF) (n = 396), or proton magnetic resonance spectroscopy (¹H-MRS) (n = 52) was used as the reference standard. UDFF was compared to noninvasive test Hepa

SUBMITTER: Xue L 

PROVIDER: S-EPMC12579052 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature