Marine-derived phlorotannins: sustainable inhibitors of multiple virulence factors in Pseudomonas aeruginosa.

ABSTRACT: Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen in diverse environments, causing plant, animal, and human infections. Its remarkable ability to resist antibiotics and deploy multiple virulence strategies is attributed to its large genome, horizontal gene transfer, and complex regulatory networks. In this study, we comprehensively investigated 15 structurally distinct phlorotannins against 18 major virulence-associated proteins, such as quorum-sensing proteins, adhesion proteins, exotoxins, siderophore receptors, secretion system components, proteases, motility, and biofilm formation. Molecular docking and 50-ns molecular dynamics simulations revealed that compounds such as 2-phloroeckol, 7-phloroeckol, phlorofucofuroeckol A, and phlorofucofuroeckol B formed strong and s

SUBMITTER: Karthikeyan A 

PROVIDER: S-EPMC12579053 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature