Unveiling the significance of ADAM12 through pan-cancer analysis and experimental verification in gastric cancer.

ABSTRACT:

Background

ADAM12, a member of the disintegrin and metalloproteinase family, has been involved in multiple cancers, yet its precise role in pan-cancer progression still remains elusive.

Methods

In our current study, we conducted a comprehensive analysis of ADAM12 expression, diagnosis, prognosis, genomic variations, DNA methylation, functional enrichment, immune infiltration as well as immunotherapy in pan-cancer utilizing public datasets. Additionally, a series of biological functional experiments of ADAM12 were performed in gastric cancer cells including cell counting kit-8 (CCK-8), colony formation, wound healing analysis, and Transwell analyses.

Results

ADAM12 expression was prominently elevated and correlated with unfavorable prognosis in most cancer types. It ex

SUBMITTER: Yang K 

PROVIDER: S-EPMC12579102 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature