Tar DNA binding protein 43, a proteinopathy with preference for olfactory structures in COVID-19 subjects.

ABSTRACT:

Background

Olfactory impairment (OI) is an early symptom of neurodegenerative diseases (ND) and COVID-19 infection. Proteinopathies associated with ND include amyloid-β (Aβ), hyperphosphorylated τ (HPτ), α-synuclein (α-syn), and Tar DNA binding protein 43 (TDP43). It is unclear whether COVID-19 infection influences the listed proteinopathies in the olfactory bulb and tract (OB/OT) aggravating the OI.

Objective

To study proteinopathies associated with ND in the brain and OB/OT in 32 subjects with COVID-19 infection and 10 age- and gender-matched controls.

Methods

Postmortem brain tissue was assessed for various proteinopathies and the OB/OT for proteinopathies, inflammatory markers and a marker for severe acute respiratory syndrome coronavirus 2 spike protein.

Resul

SUBMITTER: Libard S 

PROVIDER: S-EPMC12579175 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature