Effects of sleep deprivation on cognition and synaptic associated proteins in rodents: A systematic review and meta-analysis.

ABSTRACT:

Background

Sleep disorders are a significant risk factor for cognitive decline and Alzheimer's disease (AD). However, preclinical studies investigating the effects of sleep deprivation (SD) on cognition and synaptic proteins have produced inconsistent findings, hindering translational progress.

Objective

This systematic review and meta-analysis identify key factors moderating the effects of SD on cognition and synaptic proteins in rodent models.

Methods

Following PRISMA guidelines, we analyzed 21 eligible studies using meta-analysis, subgroup, meta-regression, and multilevel analyses to identify sources of experimental heterogeneity.

Results

SD significantly reduced synaptic proteins overall. While the global effect on cognition was not significant, subgroup an

SUBMITTER: Wang H 

PROVIDER: S-EPMC12579198 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature