Effects of systemically administered cholecalciferal and vitamin B complex on mental nerve injury in rats.

ABSTRACT: This study aimed to evaluate the effects of systemic cholecalciferol (vitamin D3) and vitamin B complex (B1, B6, B12) on crush-injured mental nerve in rats using histopathological and immunohistochemical analyses to assess nerve degeneration and regeneration. Thirty-two Wistar Albino rats were subjected to standardized mental nerve crush injury using a Yasargil aneurysm clip and divided into four groups: Control /Sham (Group 1), B vitamin (intraperitoneal) (Group2), D vitamin (oral) (Group 3), and combined (B + D) (Group 4). After 4 weeks, nerve samples were excised for histopathological evaluation (ghost cell and hyperchromatic nuclei counts) and immunohistochemical analysis (S100β and BIII tubulin scores). Data were analyzed using Generalized Linear Models with Bonferroni post-hoc tests.

SUBMITTER: Yılmaz N 

PROVIDER: S-EPMC12579215 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature