The association between gut microbiota and functional connectivity in cognitive impairment of first-episode major depressive disorder.

ABSTRACT: The pathogenesis of major depressive disorder(MDD) and cognitive impairment has been linked to gut microbiota; however, the relationship between cognitive impairment and gut microbiota in patients with MDD and their underlying mechanisms remain unclear. This study aimed to investigate the brain-gut axis involved in cognitive impairment among patients with first-episode MDD through neuroimaging and microbiome analyses. 43 microbial species were different between patients with first-episode MDD and healthy controls. Notably, the relative abundances of Amycolatopsis sp. Hca4 and Shewanella livingstonensis were lower in patients with MDD compared to healthy controls, with Amycolatopsis sp. Hca4 negatively correlated with processing speed and Shewanella livingstonensis positively correlated wit

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12579243 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature