G6PD deficiency in brain induces schizophrenia-like behaviors and synaptic dysfunction.

ABSTRACT: Schizophrenia is a severe mental disorder characterized by aberrant brain development, influenced by genetic and environmental factors, with an incompletely understood etiology. Glucose-6-phosphate dehydrogenase (G6PD), a critical enzyme in the pentose phosphate pathway (PPP), facilitates NADPH production for biosynthesis and redox homeostasis. Recent studies suggests that PPP inhibition and consequent oxidative stress contribute to schizophrenia pathogenesis. While clinical investigations have proposed a link between G6PD deficiency and schizophrenia, the underlying biological mechanisms remain unestablished. We here demonstrate that brain-specific G6PD knockout induces schizophrenia-like behaviors in mice, establishing a direct association between G6PD deficiency and schizophrenia. Prote

SUBMITTER: Wang YB 

PROVIDER: S-EPMC12579270 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature