β-Lactam vs Non-β-Lactam Antimicrobial Prophylaxis and Surgical Site Infection.

ABSTRACT:

Importance

β-lactam-based surgical antimicrobial prophylaxis (SAP) is the standard for most surgical procedures. Alternatively, and mostly due to allergies, non-β-lactam-based prophylaxis is used. The association between the use of non-β-lactam SAP and an increased risk of surgical site infection (SSI) rate has not yet been conclusively described.

Objective

To assess whether non-β-lactam vs β-lactam prophylaxis is associated with the occurrence of SSI.

Design, setting, and participants

This cohort study was based on the Swissnoso SSI surveillance system of 175 hospitals, including adult patients who underwent a major surgical procedure with SAP administration within 120 minutes prior to incision and postdischarge follow-up from January 2009 to December 2020. Patients

SUBMITTER: Largiader S 

PROVIDER: S-EPMC12579348 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature