Localising OCTA changes induced by the isometric hand-grip test to the superficial retina in neovascular age-related macular degeneration.

ABSTRACT:

Purpose

This study uses optical coherence tomography angiography (OCTA) topographical cluster analysis to localise where vascular changes occur during the isometric hand-grip test (IHGT) in eyes with neovascular age-related macular degeneration (AMD).

Methods

This prospective study included single eyes from 44 participants with neovascular AMD. Systemic blood pressure (BP) and macular 6 × 6 mm OCTA scans were obtained before the IHGT, during the IHGT, and after the IHGT. The main outcome was the change in processed OCTA signal (%), measured within high-density (126 × 126) grids and analysed by topographical clusters across the superficial retina, deep retina, and choriocapillaris. Results were compared against test-retest thresholds to differentiate true IHGT-induced changes

SUBMITTER: Trinh M 

PROVIDER: S-EPMC12579405 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature